基于光反应性 (甲基) 烯酸和酸的抗菌涂层 - - 对 Staphylococcus epidermidis 的有效性
Agnieszka Kowalczyk1, Agata Kraśkiewicz1, Agata Markowska-Szczupak2
1Department of Chemical Organic Technology and Polymeric Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, 70-322 Szczecin, Poland.
Polymers
|September 14, 2024
概括
酸 (FA) 增强了由可光聚合的寡合物制成的抗菌涂层. 这种新型涂层有效地抑制了Staphylococcus epidermidis生物膜的形成,显示出更好的附着性和硬度.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 聚合物化学 聚合物化学
背景情况:
- 抗微生物涂层对于防止生物膜形成至关重要.
- 可光聚合材料提供高效的涂层解决方案.
- 酸 (FA) 是一种具有潜在生物活性的天然化合物.
研究的目的:
- 开发和表征一种新的抗微生物涂层粘合剂,使用酸 (FA) 修饰的光聚合性寡合物.
- 研究FA对光聚合动力学,化学结构,涂料的机械,光学和抗菌性能的影响.
- 评估FA修饰涂层对抗Staphylococcus epidermidis生物膜的有效性.
主要方法:
- 无溶液的UV-LED启动的 (甲基) 酸寡合物和烯的光聚合.
- 光差扫描热度计 (光-DSC) 用于运动研究.
- 里埃变换红外光谱 (FTIR) 用于化学结构分析.
- 机械测试 (粘合,硬度) 和光学测量 (光泽,DOI).
- 对抗 Staphylococcus epidermidis 生物膜的抗菌分析.
主要成果:
- 酸对紫外线交联产生了积极的影响,减少了过程减速,增加了单体转化.
- 增加的FA含量出乎意料地提高了涂层的粘合力和硬度.
- 用0.9%重量%的FA涂层显示出出色的抗菌活性,在24小时后将细菌数量降至1.98日志CFU/mL.
- 所有涂料都表现出高硬度,光泽度 (>80 G.U.). ) 和 DOI 值 (30-50 个AU). ) 的情况.
结论:
- 酸是开发有效的抗微生物光聚合涂料的有希望的添加剂.
- 经过FA修饰的涂层提供了理想的机械,光学和强大的抗菌性能的平衡.
- 这种新型材料为防止Staphylococcus epidermidis生物膜形成提供了一个可行的解决方案.
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