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通过AMPS共聚合物宏体中的共单体选择量身定制水凝板的特性

Jinjutha Daengmankhong¹, Thanyaporn Pinthong¹, Sudarat Promkrainit¹

¹Biopolymer Group, Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.

|September 14, 2024

概括

使用2-烯胺-2-甲基-1-硫酸盐 (AMPS) 与N-乙烯胺 (HEA) 和3-硫烯酸盐 (SPA) 的新型水凝显示出改善生物医学用途的胀和机械性能.

科学领域:

材料科学材料科学材料科学
聚合物化学聚合物化学
生物医学工程生物医学工程

背景情况:

由于其高含水量和可调节性质,水凝在生物医学应用中至关重要.
开发具有增强胀和机械强度的先进水凝对于改善药物输送和伤口管理的性能至关重要.

研究的目的:

为了合成和描述基于2-烯胺-2-甲基-1-硫酸盐 (AMPS) 共聚合物的新型水凝.
研究纳入N-乙烯胺 (HEA) 和3-硫烯酸酸盐 (SPA) 对水凝特性的影响.
评估这些改性水凝在药物输送和伤口管理应用中的潜力.

主要方法:

合成基于AMPS的共聚合物 (poly(AMPS-stat-CEA-stat-MAA,PACM)) 并将它们与基乙烯 (AGE) 修改成巨型分子 (PACM-AGE).
进一步合成和AGE修改包含HEA (PAHCM-AGE) 和SPA (PASCM-AGE) 的共聚物.
使用1H NMR,FT-IR和GPC进行表征;评估水凝膨胀,水含量和机械性能 (抗拉强度,延长);初步药物输送研究.

主要成果:

PASCM-AGE水凝显示出优异的膨胀比率和保持水分 (在30分钟内含有约92%的水分).
与PACM-AGE (2.5 MPa, 47%) 相比,PAHCM-AGE水凝具有更高的抗拉强度 (5.8 MPa),但延伸率较低 (19%).
PASCM-AGE水凝显示出高抗拉强度 (3.7 MPa) 和更大的延伸 (92%) 的平衡,表明了多功能性质调整.

结论:

用HEA和SPA修改的基于AMPS的宏分子为先进的水凝应用提供可调节的膨胀和机械性能.
PASCM-AGE水凝的增强性能使其非常适合需要显著的吸水和灵活性的应用.
这些修改后的水凝对伤口管理和药物输送系统有很大的希望,特别是当与光激活疗法的光敏剂相结合时.

关键词:

2-亚克利胺-2-甲基-1-硫酸盐的盐.生物医学应用程序这种水凝是水凝.它们是宏分子.光敏化器是一种光敏化剂.

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