等待期对IVF-ICSI患者最初不良的阴道微生物组组成的影响
Alexandra Petra Bielfeld1, Dunja Maria Baston-Buest1, Philippos Edimiris1
1Department of Obstetrics/Gynecology and Reproductive Endocrinology and Infertility (UniKiD), University of Duesseldorf Medical Center, Moorenstrasse 5, 40225 Duesseldorf, Germany.
Journal of clinical medicine
|September 14, 2024
概括
在不孕期患者的阴道微生物组可以在几个月内自发地转变为有利的形状. 这凸显了阴道微生物组的动态性质及其在没有干预的情况下自然改善的潜力.
科学领域:
- 生殖医学 生殖医学
- 微生物组研究 微生物组研究
- 妇女健康 妇女健康
背景情况:
- 在全球范围内,不孕不育影响着许多夫妇,其中阴道微生物群发挥着至关重要的作用.
- 不良的阴道微生物组与降低生育能力的结果有关.
- 了解微生物组的动态是优化生育治疗的关键.
研究的目的:
- 为了研究不孕期患者阴道微生物组不良特征的自发逆转能力.
- 评估等待时间在受精治疗前对阴道微生物群状态的影响.
- 确定与自发向有利微生物组转移相关的因素.
主要方法:
- 观察性前性队列研究,涉及76名德国大学医院生育中心的不孕症患者.
- 使用商业测试对前性收集的拭子进行阴道微生物组分析.
- 具有不利概况的患者推迟治疗,并在周期内采样,直到概况改善或开始治疗.
主要成果:
- 最初,23/76名患者呈现出不利的 ("低") 阴道微生物组特征.
- 在三个月内,75%的这些患者经历了自发的转变到一个更有利的形状.
- 乳杆菌crispatus的存在与自发有利微生物组转移的可能性更高有关.
结论:
- 阴道微生物组在非生育个体中表现出显著的自然波动.
- 一个不利的微生物组特征可以在几个月内自发地变成一个有利的特征,而不需要具体的干预.
- 这些发现表明,等待期可能允许在一些不孕期患者中改善自然微生物群.
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