释放诊断潜力:对脊柱结核病中的生物标志物的系统审查
Andre Marolop Pangihutan Siahaan1, Alvin Ivander2, Steven Tandean1
1Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, Indonesia.
Journal of clinical medicine
|September 14, 2024
概括
脊柱结核病 (STB) 的早期诊断可以通过使用新的生物标志物来改善. 像中性粒细胞与淋巴细胞比率 (NLR) 等标记物的组合和特定的miRNAs显示STB的高诊断准确性.
科学领域:
- 生物化学和分子生物学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 脊柱结核病 (STB) 由于其多样化的临床表现,经常被误诊.
- 准确和早期诊断STB对于有效的患者管理和结果至关重要.
- 对于STB的现有诊断方法可能是有限的,需要探索新的生物标志物.
研究的目的:
- 系统地审查和识别潜在的生物标志物,以便早期和准确地诊断脊髓结核病.
- 评估各种生物标志物的诊断准确性,包括血液学,炎症,细菌和基于RNA的标志物.
主要方法:
- 在多个数据库中进行了系统的文献搜索.
- 包括了针对脊髓结核患者血清生物标志物的研究.
- 使用QUADAS-2工具进行了包含的研究的质量评估.
主要成果:
- 一些生物标志物,包括中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR),IFN-γ,CXCR3,CXCL9,CXCL10,PSMB9,STAT1,TAP1和miRNA组合,显示出显著的诊断潜力.
- 这些标志物在区分STB与其他脊柱疾病方面表现出准确性,并提供了有关疾病严重程度的见解.
- 结合多个生物标志物被强调为一种提高诊断精度的策略.
结论:
- 生物标志物的组合,特别是中性粒细胞与淋巴细胞的比率 (NLR),PSMB9,STAT1和某些微RNA (miRNA),对脊髓结核病的诊断准确度有希望.
- 这些生物标志物可能会彻底改变性病的早期和准确诊断,从而改善患者的护理.
- 建议将这些生物标志物纳入临床实践,以获得更好的患者结果.
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