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多系统性缩中的食道动力不良:一个回顾性横截面研究
Rumi Ueha1,2, Misaki Koyama2, Akiko Seto3
1Swallowing Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Journal of clinical medicine
|September 14, 2024
概括
食道动力障碍 (ED) 在多系统性缩 (MSA) 患者中很常见,即使没有严重的症状,也经常发生. 高分辨率计量 (HRM) 对于检测MSA中的ED至关重要,因为它经常错过.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
- 吞障碍 吞障碍 吞障碍
背景情况:
- 多重系统性缩 (MSA) 经常伴有食障碍和食道运动障碍 (ED).
- 在MSA中ED的确切性质和临床相关性仍然不太清楚.
- 了解ED对于管理MSA患者的生活质量至关重要.
研究的目的:
- 评估MSA患者中ED,消化不良和临床因素之间的关联.
- 在MSA中使用高分辨率测量仪 (HRM) 进行ED的表征.
主要方法:
- 来自东京大学医院的74名MSA患者的回顾性审查 (2017-2022年).
- 纳入标准:吞检查,食道检查和HRM.
- ED分类遵循芝加哥分类v4.0.0.0的标准.
主要成果:
- 65%的患者有食道内静止; 46%的患者表现出异常的食道上 (UES) 静止压力.
- 高度严重的MSA与食障碍和UES功能异常相关 (p <0.05).
- 不有效的食道运动是HRM检测到的最常见的ED类型.
结论:
- 消化管动力障碍 (ED) 在多系统性缩 (MSA) 患者中非常普遍.
- 虽然严重的MSA可能会导致失消,但ED可以发生不论疾病的严重程度.
- 客观食道测量 (食道图或HRM) 对于诊断MSA的ED至关重要,因为症状往往缺席或微妙.
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