探索急性冠状动脉综合征,下呼吸道感染和大气污染之间的关系
Paweł Muszyński1,2,3, Elżbieta Pawluczuk2, Tomasz Januszko1
1Department of Invasive Cardiology, Medical University of Bialystok, M. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.
Journal of clinical medicine
|September 14, 2024
概括
下呼吸道感染 (LRTI) 在急性冠状动脉综合征 (ACS) 患者中增加冠状动脉血栓形成的风险. 对细颗粒物 (PM2.5) 的暴露也与这些患者的LRTIs有关.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 环境健康 环境健康
背景情况:
- 呼吸道感染与急性冠状动脉综合征 (ACS) 通过炎症和氧化应激有关.
- 提出的机制包括斑块不稳定,破裂和血栓形成,导致ACS.
- 这项研究调查了ACS患者冠状动脉血栓形成和下呼吸道感染 (LRTI) 的风险因素.
研究的目的:
- 评估ACS患者冠状动脉血栓形成的风险因素.
- 评估ACS患者下呼吸道感染 (LRTI) 的风险因素.
- 在ACS中探索空气污染和LRTIs之间的关联.
主要方法:
- 来自876名ACS患者的临床和空气污染数据的分析 (2014年1月 - 2018年12月).
- 统计分析包括学生的t测试,曼-惠特尼U测试,奇二测试和赔率比率计算.
- 在ACS住院治疗前三天,评估大气气溶 (PM2.5) 度.
主要成果:
- 在ACS患者中,LRTIs发生在9.13%.
- 患有LRTI的患者患冠状动脉血栓的风险增加了2.49倍.
- LRTI患者表现出较高的炎症标志物,年龄较大,BMI较低,心房率较高,以及更高的先前PM2.5暴露.
结论:
- 冠状动脉血栓形成在患有LRTI的ACS患者中更为频繁.
- 在ACS患者中,在前三天增加的PM2.5暴露与LRTI有关.
- 研究结果强调了呼吸道感染,空气污染和不良心血管事件之间的联系.
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