皮肤新生病症 复杂化治疗用单克隆抗体治疗多发性硬化症
Floriana Bile1, Maddalena Sparaco2, Eleonora Ruocco3
1Department of Advanced Medical and Surgical Sciences, 2nd Division of Neurology, University of Campania Luigi Vanvitelli, Via Sergio Pansini, 5, 80131 Naples, Italy.
Journal of clinical medicine
|September 14, 2024
概括
多发性硬化症 (MS) 的单克隆抗体 (mAb) 治疗没有明确与皮肤癌风险的联系. 建议在开始治疗之前进行皮肤学查,并根据个体患者的个人资料进行后续检查.
科学领域:
- 神经学 神经学
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 治疗已经演变为许多疾病修饰疗法.
- 单克隆抗体 (mAbs) 是高效的多发性硬化症治疗方法,具有有针对性的机制和一般有利的风险概况.
- 对于某些MS疗法 (包括mAbs) 的潜在皮肤癌风险存在担忧,尽管皮肤病学后续检查不是标准.
研究的目的:
- 在接受单克隆抗体 (mAb) 治疗的多发性硬化症患者中审查皮肤恶性瘤病例.
- 探索潜在的病理生理机制,将mAb疗法与皮肤癌联系起来.
- 评估这些患者是否需要定期进行皮肤学随访.
主要方法:
- 在PubMed上进行了全面的文献搜索,没有日期限制.
- 包括以英语出版的同行评审文章,不包括重复版.
- 在2001年至2024年间发表的54项相关研究被选中进行分析.
主要成果:
- 对54项研究的审查发现,单克隆抗体 (mAb) 治疗与MS患者皮肤癌风险增加之间没有明确的关联.
- 目前对mAb治疗的禁忌包括癌症史.
- 建议在开始mAb治疗之前进行个性化皮肤学查.
结论:
- 现有证据并未确定mAb治疗与MS患者皮肤癌之间的明确联系.
- 在mAb治疗前建议进行皮肤学查.
- 治疗后的皮肤病随访应根据每个患者的特定风险因素进行个性化.
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