患有急性淋巴细胞白血病的儿科患者的超白血细胞症:人口统计和临床特征
Małgorzata Monika Mitura-Lesiuk1, Maciej Dubaj2, Aleksandra Dembowska2
1Department of Paediatric Haematology, Oncology, and Transplantology, Medical University of Lublin, 20-093 Lublin, Poland.
Journal of clinical medicine
|September 14, 2024
概括
儿童急性淋巴细胞白血病 (ALL) 的超白血细胞症与年长男孩和T-ALL有关,具有更高的死亡率和感染风险. 这种情况显著影响ALL的预后和临床结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 白细胞生物学 白细胞生物学
背景情况:
- 超白细胞症,定义为白细胞数量>50,000/mm3.
- 在近20%的儿科急性淋巴细胞白血病 (ALL) 病例中发生.
- 它被确定为ALL的不良预后因素.
研究的目的:
- 描述患有超白细胞瘤的儿科ALL患者的人口统计和临床特征.
- 为了研究超白细胞症和白细胞计数之间的关系.
- 评估儿科ALL中超白细胞瘤症的预后影响.
主要方法:
- 医疗数据的回顾性分析.
- 研究人口:在2017-2024年期间诊断和治疗ALL的儿科患者.
- 纳入标准:ALL的诊断和可用的医疗数据.
主要成果:
- 在97名儿科ALL患者中,有10.3%的患者表现出高白细胞症.
- 超白细胞症在患有T-ALL的老男孩中更为普遍.
- 与更高的死亡率,,改变的血小板/中性粒细胞数量,增加的LDH和增加的感染发病率有关.
结论:
- 超白细胞症是儿科ALL的一个显著的临床和预后因素.
- 早期识别和治疗超白细胞瘤是至关重要的.
- 需要进一步研究管理ALL中的超白细胞症.
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