相关实验视频
Updated: Jun 13, 2025

12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
10.5K
与布罗卢西祖马布相关的炎症和血管炎
António Campos1,2, Carolina Mota1, Francisco Caramelo3
1Ophtalmology Department, Centro Hospitalar de Leiria, 2410-197 Leiria, Portugal.
Journal of clinical medicine
|September 14, 2024
概括
与aflibercept相比,布罗卢齐祖马布在新血管年龄相关黄斑变性 (nAMD) 患者中显示眼内炎症 (IOI) 和视网膜血管炎 (RV) 的发生率显著更高. 布罗卢齐祖马布注射的严重并发症风险明显大于败血症内.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 需要静脉内注射 (IVI) 来治疗.
- 布罗卢齐祖马布和阿弗利伯塞普是用于nAMD的抗VEGF药物.
- 眼内炎症 (IOI) 和视网膜血管炎 (RV) 是IVI的潜在并发症.
研究的目的:
- 在nAMD患者中比较brolucizumab和aflibercept之间IOI的流行率.
- 为了比较两种疗法IOI的几率比率 (ORs) 与败血性内耳炎的风险.
- 为了评估与布罗卢齐祖马布与aflibercept相关的闭塞视网膜血管炎 (RV) 的风险.
主要方法:
- 这是一项回顾性研究,比较了468个IVI的布罗卢齐祖马布 (117只眼睛) 和2884个IVI的阿弗利伯塞普 (305只眼睛).
- 从2021年12月到2023年6月收集的数据.
- 计算IOI和VR发病率和几率比率,与败血性内耳炎的文献值相比.
主要成果:
- 布罗卢齐祖马布队列显示了3.42%的IOI发病率 (膜炎,炎,RV),相比之下,aflibercept队列中的0.66%.
- 每次注射IOI的发生率显著高于brolucizumab (0.855%) 和aflibercept (0.069%,p = 0.004).
- 布鲁西祖马布IOI的OR为20.15 (p < 0.001),明显高于阿弗利塞普特 (1.49,p = 0.646) 和20倍大于败血症内炎的风险. 对于VR与布罗卢齐祖马布的OR为4.6.
结论:
- 与aflibercept相比,布罗卢齐祖马布与IOI和封闭性RV的风险相对较高.
- 布罗卢齐祖马布IVI的视力威胁并发症的风险超过了败血症内.
- 眼科医生在为nAMD选择抗VEGF治疗时应考虑这些风险.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
120
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
120
Inflammatory Bowel Disease I: Ulcerative Colitis
153
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
153
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
98
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
98
Inflammatory Bowel Disease II: Crohn's Disease
201
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
201
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
145
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
145
Inflammation
53.2K
Overview
53.2K

