Melatonin 对运动诱导的氧化应激的影响 肥胖成年人接受多学科减肥计划
Antonello E Rigamonti1, Federico M Rubino2, Diana Caroli3
1Department of Clinical Sciences and Community Health, University of Milan, 20129 Milan, Italy.
Journal of clinical medicine
|September 14, 2024
概括
黑素补充剂可能会通过增加氧化应激和炎症来损害肥胖个体的减肥努力,可能会否定减肥计划的心脏代谢益处.
科学领域:
- 心脏代谢健康状况
- 肥胖问题研究研究
- 氧化应激和炎症的发生
背景情况:
- 肥胖与增加的氧化应激和慢性炎症有关.
- 抗氧化剂梅拉因被研究其增强减肥效果的潜力.
研究的目的:
- 评估黑激素对运动后氧化应激和炎症的影响.
- 评估黑激素在减肥计划 (BWRP) 期间对心脏代谢标记物的影响.
主要方法:
- 18名肥胖成年人参加了为期2周的BWRP.
- 参与者每天接受2毫克黑激素或安慰剂.
- 在协议的开始和结束时进行了急性运动.
主要成果:
- 在两组中,BWRP降低了BMI和腰围.
- 矛盾的是,黑素治疗在运动后增加了氧化应激标志物 (d-ROMs,HbSSG).
- 黑色素取消了BWRP诱导的IL-6水平的降低,与安慰剂不同.
结论:
- 在接受BWRP的肥胖个体中,黑色素表现出有条件的亲氧化作用.
- 补充黑激素可能是有害的,阻碍了减肥的心脏代谢改善.
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