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绘制肝细胞癌的隐藏地形:通过使用美国最大的数据集,在20年内探索发病率和死亡率的区域差异

Yazan Abboud¹, Vraj P Shah¹, Michael Bebawy¹

¹Department of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

Journal of clinical medicine

|September 14, 2024

概括

肝细胞癌 (HCC) 发病率和死亡率在美国各地区增加,直到2014-2016年,然后下降. 南部和西部地区显示出最高的比率,南方地区的HCC负担增长最快.

科学领域:

肝胆道癌症肝胆道癌症
癌症流行病学癌症流行病学
公共卫生监督公共卫生监督

背景情况:

肝细胞癌 (HCC) 负担在美国人口中显著变化.
在HCC发病率和死亡率的地理差异与诸如病毒性肝炎,代谢功能障碍相关的脂肪性肝病和治疗机会等因素有关.

研究的目的:

综合评估美国各地区HCC发病率和死亡率的地理差异.
为了确定HCC负担的趋势和区域差异.

主要方法:

利用了美国癌症统计局 (USCS) 的数据 (2001-2021) 关于HCC发病率和国家卫生统计中心 (NCHS) 的数据 (2000-2022) 关于死亡率.
分析了根据美国地理区域 (西部,中西部,东北部,南部) 和种族/种族分类的年龄调整率.
员工联络点回归来估计时间趋势 (APC,AAPC).

主要成果:

在西方 (7.38) 和南方 (6.85) 每10万人口中观察到最高的HCC发病率.
总体发生率增加到2015年,然后下降 (APC = -2.29);南方显示出最大的发生率增加 (AAPC = 2.74).
在南方 (5.02) 和西部 (4.99) 每10万人口中发现HCC死亡率最高;整体死亡率增加到2013年,然后下降 (APC = -1.59).

结论:

美国所有地区的HCC发病率和死亡率都在上升,直到大约2014-2016年,随后稳定和下降.
区域差异很大,西部和南部的比例最高,南部增长速度最快.
抗病毒疗法的引入和区域人口/社会经济因素可能会影响这些趋势,需要进一步调查.

关键词:

流行病学流行病学地理地理地理地理.健康差异的差异在健康上肝细胞癌是肝细胞癌.发生率的发生率.死亡率死亡率

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