轻度超重与生存率之间的关联:在撒丁岛蓝色区对异常长寿人口的研究
Giovanni Mario Pes1,2, Alessandra Errigo1, Maria Pina Dore1,3
1Dipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Clinica Medica, Viale San Pietro 8, 07100 Sassari, Italy.
Journal of clinical medicine
|September 14, 2024
概括
轻度超重与非常老的成年人更长的生存时间有关. 这一发现表明,当建议对身体质量指数 (BMI) 略高的老年人进行卡路里限制时,需要谨慎.
科学领域:
- 老年学是一门学科.
- 长寿研究的研究.
- 营养流行病学 营养流行病学
背景情况:
- 超重和肥胖通常是早期死亡的风险因素.
- 然而,轻度超重可能与老年人群的并发症减少和生存率增加有关.
- 这项研究考察了非老年人的人类参数和生存率.
研究的目的:
- 为了研究身体质量指数 (BMI) 与在撒丁岛的一群非老年人的生存率之间的关联.
- 为了确定轻度超重是否会在极端老年时提供生存优势.
- 为老年人体重管理提供临床建议.
主要方法:
- 在撒丁岛,对200名非老年人 (89岁以上) 进行了长达6年的随访.
- 收集的数据包括人体测量 (身高,体重),年龄,性别,并发症,残疾和饮食.
- 用多变量分析,包括Cox比例危险回归来评估生存关联.
主要成果:
- 轻度超重 (BMI 25.0-27.2 kg/m2 取决于性别) 与体重不足或肥胖相比,与显著更长的生存时间相关 (p < 0.0001).
- 观察到BMI和生存率之间的反转-U关系,表明轻度超重的生存优势.
- 六年后,14%的参与者仍然活着,男性的生存率略高.
结论:
- 轻度超重,但不是严重超重,与非老年人的寿命延长有关.
- 临床医生应该小心建议对轻度超重的老年患者进行卡路里限制.
- 这些发现表明,轻度超重对极端老年人的潜在生存益处.
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