在眼科环境中研究的流动诱导腐蚀
Marco Ferroni1,2, Francesco De Gaetano1,2, Dario Gastaldi1
1Chemistry Materials and Chemical Engineering Department "Giulio Natta", Politecnico di Milano, 20133 Milan, Italy.
Materials (Basel, Switzerland)
|September 14, 2024
概括
这项研究调查了药物输送装置在眼睛中的腐蚀. 更高的眼液流量增加了的降解率,影响了设备设计.
科学领域:
- 生物材料科学 生物材料科学
- 腐蚀工程 腐蚀工程
- 眼科医生 眼科 眼科
背景情况:
- 的生物降解受到流体动力学的影响.
- 没有研究涉及玻璃体幽默对生物吸收器件的影响.
- 设备是潜在的眼科药物输送载体.
研究的目的:
- 在眼科环境中研究流动诱导的腐蚀.
- 确定用于眼科药物输送应用的降解机制.
- 将眼流诱导的剪切应力 (FISS) 与腐蚀率相关联.
主要方法:
- 结合实验和计算流体动力学 (CFD) 建模.
- 用于设计复制眼睛FISS的实验条件的CFD.
- 在控制FISS的生物反应器系统中进行定制的腐蚀测试.
主要成果:
- 在纯样本上观察到的一致的腐蚀机制.
- 腐蚀率随着FISS的增加而增加:1.9,2.7和3.4微米/天在0,0.01和0.032Pa时.
- 较高的剪切应力导致腐蚀产品的冲洗效应.
结论:
- 动态的眼睛环境显著影响腐蚀.
- 腐蚀速率取决于眼流诱导的剪切应力.
- 这些发现对于设计基于的眼科药物输送装置至关重要.
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