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Updated: May 7, 2026

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在动物中使用液体染色学-并联质谱法评估维普德格兰特的稳定性和药物动力学概况

Hae-In Choi1, Jinyoung Choi1, Jin Woo Kim1

  • 1Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.

Molecules (Basel, Switzerland)
|September 14, 2024
PubMed
概括

一种新的PROTAC药物Vepdegestrant有效地针对乳腺癌治疗中的ERα. 这项研究开发了一种经过验证的LC-MS/MS方法来分析vepdegestrant,揭示了其药理动力学特性和稳定性,用于进一步的药物开发.

关键词:
在ARV-471中使用.这是LC-MS/MS.这就是PROTAC.药物动力学 药物动力学稳定的稳定性 稳定的稳定性验证验证的时间这是一个巨大的转移.

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