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溶剂相对容量的影响在抽样喷雾质谱法中的溶剂相对容量

Thomas Michael Muggli¹, Stefan Schürch¹

¹Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland.

Molecules (Basel, Switzerland)

|September 14, 2024

概括

溶剂特性显著影响冲刷剂喷雾的电离效率. 高相对电容度 (>25) 的溶剂通过控制喷气形成以获得更好的分析结果来促进最佳的离子生成.

科学领域:

分析化学分析化学
物理化学物理化学

背景情况:

电子喷雾电离技术对于质谱学至关重要.
抽样喷雾电离 (SSI) 为直接样本分析提供了一种多功能方法.
了解溶剂效应是优化SSI性能的关键.

研究的目的:

为了研究溶剂特性如何影响冲刷喷雾电离化中的离子生成.
确定SSI中稳定和可重复的电子喷雾的关键参数.
为了将溶剂特性与离子产量和喷气行为的相关性.

主要方法:

检查了各种各样的溶剂,它们的相对电容性,表面张力和粘度各不相同.
评估了由这些溶剂形成的电子喷雾剂的稳定性和可重复性.
在不同的溶剂成分和应用电位下分析了泰勒形状和喷气特性.
将SSI性能与传统的电子喷雾电离和纸喷雾电离相比较.

主要成果:

对于SSI来说,溶剂组成,应用潜力和流速的关键平衡是必不可少的.
溶剂相对电容性是影响泰勒形和喷气形成的主要因素.
具有相对导电率> 25的溶剂可以达到最大的离子产量,形成短喷气.
具有较低相对电容性的溶剂需要添加甲醇 (20-60%) 来防止滴滴脉冲并优化喷气长度.

结论:

溶剂的相对电容性决定了SSI中的喷射成型和电离效率.
优化溶剂特性对于最大限度地提高离子产量和确保在抹布喷雾离子化中可重现的结果至关重要.
这些发现为使用SSI的直接分析应用程序的方法开发提供了宝贵的见解.

关键词:

泰勒形的形成是泰勒形.环境的离子化环境.电子喷雾电离化电离化纸张喷雾纸张喷雾相对的允许性相对的允许性.抽样喷雾质谱法质谱仪

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