大量营养素和微量营养素摄入量对中风的因果关系:一个双样本的孟德尔随机化研究
Guozhang Dong1, Wanqian Xu2, Lin Xu1
1The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing 210009, China.
Nutrients
|September 14, 2024
概括
摄入,维生素C和维生素B9可能会降低中风风险,特别是心血管和小血管中风. 需要对维生素B6进行进一步的研究.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 心血管疾病研究研究
背景情况:
- 调查营养摄入与中风的因果关系对于预防至关重要,但观察性研究面临混和反向因果关系.
- 门德尔随机化 (MR) 提供了一种可靠的方法来评估营养等可修改的风险因素对疾病的因果关系.
研究的目的:
- 估计各种营养素摄入量与中风风险及其亚型之间的因果关系,使用双样本孟德尔随机化方法.
- 确定可以针对中风预防公共卫生战略的关键营养素.
主要方法:
- 进行了对两个样本的门德尔随机化 (MR) 分析.
- 来自15个全基因组关联研究 (GWAS) 的4个宏观营养素和14个微量营养素的遗传总结统计数据.
- 脑卒中和亚型数据来源于MEGASTROKE联盟.
主要成果:
- 基因预测较高的含量与心血管血栓性中风风险降低有显著关联 (OR:0.011).
- 维生素C摄入量与降低心血管血栓性中风风险显著相关 (OR:0.759).
- 维生素B9摄入量与小血管中风风险降低有关 (OR:0.574).
- 维生素B6与增加大动脉中风风险的潜在关联 (OR:1.546),需要谨慎解释.
- 也显示了有迹象表明可以降低任何中风和缺血性中风的风险.
结论:
- ,维生素C和维生素B9在中风预防中起着保护作用,支持在公共卫生倡议中考虑它们.
- 维生素B6与大动脉中风风险之间的关联需要进一步调查,因为支持基因变异的数量有限.
- MR 分析为营养与中风的关系提供了宝贵的见解,指导未来的研究和预防策略.
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