化物与美国儿童和青少年骨矿物质密度之间的关联:试点研究
Haichen Kong1, Zihao He1, Hui Li1
1Arthritis Clinic and Research Center, Peking University People's Hospital, Peking University, Beijing 100044, China.
Nutrients
|September 14, 2024
概括
从水和血中获得较高的化物暴露与儿童和青少年的骨矿物质密度 (BMD) 较低有关. 在这项全国性研究中,尿液化物水平与骨硬化没有显著的关联.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 骨生物学 骨生物学
背景情况:
- 化物广泛用于牙健康,但其对骨健康的影响,特别是儿童的骨矿物质密度 (BMD),需要进一步调查.
- 了解环境化物暴露与骨发育之间的关系对于公共卫生至关重要.
- 之前的研究已经产生了关于化物对骨健康的影响的混合结果.
研究的目的:
- 研究美国儿童和青少年不同来源的化物暴露 (水,血,尿液) 与全身减去头骨矿物质密度 (TBLH BMD) 之间的关联.
- 探索化物水平与骨硬化之间的线性和非线性关系.
- 提供关于化物在关键生长时期对骨健康的影响的见解.
主要方法:
- 利用了2015-2016年国家健康和营养检查调查 (NHANES) 的数据,其中包括1413名参与者.
- 使用离子特异电极测量水,血和尿液中的化物度.
- 通过双能X射线吸收度 (DXA) 评估TBLH BMD,并使用加权通用线性回归和限制立方线 (RCS) 模型分析关联.
主要成果:
- 在饮用水和血中的化物度与TBLH BMD之间发现了反向关联.
- 确定了水和血中化物水平与TBLH BMD之间的显著非线性关系.
- 在分析的人群中,尿液化物水平和TBLH BMD之间没有发现显著的关联.
结论:
- 饮用水和血中的化物暴露与儿童和青少年的骨矿物质密度相反相关.
- 化物暴露与骨健康之间的关系是复杂的,可能是非线性的.
- 需要进一步的研究来阐明化物暴露对儿科骨健康的机制和长期影响.
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