识别与甜味偏好相关的单核酸多态性,用于与肥胖相关的多基因风险评分
1Department of Food Science and Nutrition, Keimyung University, Daegu 42601, Republic of Korea.
Nutrients
|September 14, 2024
概括
与甜味偏好相关的遗传变异,如rs4861982,增加肥胖风险,特别是在男性中. 吸烟等环境因素也与肥胖相关,凸显了遗传学和生活方式的复杂相互作用.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 肥胖问题研究研究
- 营养科学 营养科学
背景情况:
- 甜味偏好是一种复杂的特征,受遗传和环境因素的影响.
- 了解甜味偏好的遗传基础可能会为肥胖风险提供见解.
- 全基因组关联研究 (GWAS) 是识别与复杂特征相关的遗传变异的强大工具.
研究的目的:
- 为了识别与甜味偏好相关的单核酸多态 (SNP).
- 描述与甜味偏好相关的遗传位置.
- 开发基于SNP的多基因风险评分 (PRS) 并评估它们与肥胖风险的关联.
主要方法:
- 利用来自18499名女性和10878名男性的GWAS数据集进行基因定型.
- 进行全基因组关联分析和功能注释.
- 从677个与甜味偏好相关的SNP中使用权重方法计算PRS.
- 采用Cox比例危险建模来估计肥胖发病率的危险比率 (HR).
- 测试了PRS,吸烟和饮食成分与肥胖之间的相关性.
主要成果:
- rs4861982的TT基因型显著增加了男性的肥胖风险 (组合分析HR = 1.259,p = 0.025).
- 蛋白氨酸酸酶受体O型 (PTPRO) 与甜味偏好有很强的关联,与肥胖风险有积极的相关性.
- 增加吸烟 (10包年) 与男性肥胖风险更高显著相关 (HR = 1.024).
结论:
- 发现了 rs4861982,甜味偏好和肥胖之间存在显著的关联,特别是在男性中.
- 偏爱甜味的遗传倾向可能会导致肥胖风险.
- 像吸烟这样的环境因素与遗传因素相互作用,影响男性肥胖风险.
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