维生素D,炎症标记物和儿童胰岛素抵抗之间的关系
Omer Okuyan1, Seyma Dumur2, Neval Elgormus3
1Department of Pediatrics, Medicine Hospital, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, Turkey.
Nutrients
|September 14, 2024
概括
儿童维生素D缺乏与较高的炎症标志物和胰岛素抵抗 (IR) 有关. 补充维生素D可能有助于减少炎症和预防儿科患者的IR.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养生物化学 营养生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 胰岛素抵抗 (IR) 是儿童群体日益关注的问题,通常与炎症有关.
- 血液炎症标志物和维生素D水平越来越被认为是代谢功能障碍的潜在贡献者.
研究的目的:
- 研究25-氧维生素D (25(OH) D水平和炎症性血液学比率 (NLR,PLR,SII,MHR,PAI) 与儿童胰岛素抵抗 (IR) 之间的关系.
- 探索维生素D在调节全身炎症和胰岛素敏感性方面的潜在作用.
主要方法:
- 一项涉及210名6-18岁儿童的横截面研究,分为具有和没有IR的组.
- 分析维生素D状况,禁食胰岛素,HOMA-IR,HOMA-β,QUICKI和炎症标志物,包括中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),全身免疫炎症指数 (SII),单细胞/HDL-C的比率 (MHR) 和血无源指数 (PAI).
主要成果:
- 与对照组相比,IR患者的儿童表现出明显更高的NLR,PLR,SII,MHR,空腹胰岛素,PAI,HOMA-IR和HOMA-β,以及较低的QUICKI.
- 在正常维生素D水平的儿童中观察到较低的NLR,SII和MHR水平.
- 与缺乏或缺乏维生素D水平相比,正常维生素D水平的儿童的PLR显著较低.
结论:
- 儿童维生素D缺乏与循环炎症标志物升高和胰岛素敏感性受损有关.
- 维生素D补充剂可能提供一种治疗策略,以减轻IR和减少儿童的全身炎症.
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