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来自不同南瓜品种的胡卜素对人类神经母细胞瘤SH-SY5Y细胞产生细胞毒性作用

Nicola Pinna¹, Federica Ianni¹, Carmela Conte¹

¹Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy.

|September 14, 2024

概括

黄瓜胡卜素提取物通过对神经母细胞瘤细胞表现出细胞毒性作用,显示出潜在的抗癌特性. 这些提取物还具有抗氧化活性,这表明它们可以用作补充癌症治疗.

科学领域:

营养科学和植物化学.
癌症研究和药理学.

背景情况:

黄瓜 (Cucurbita spp.) 是一种植物. 富含营养和生物活性化合物,具有潜在的健康益处.
来自南瓜肉质的胡卜素因其治疗性质而引起人们的兴趣.

研究的目的:

评估八种南瓜品种的胡卜素提取物对SH-SY5Y神经母细胞瘤细胞的细胞毒性和抗氧化活性.
描述提取物的胡卜素特征,并评估它们作为抗癌剂的潜力.

主要方法:

准备了八种南瓜品种 (C. moschata和C. maxima) 的胡卜素提取物.
在SH-SY5Y神经母细胞瘤细胞上评估了细胞毒性.
在体外抗氧化活性使用ABTS和ORAC试验进行了评估.
高性能染色学被用于胡卜素的概况.

主要成果:

黄瓜胡卜素提取物对神经母细胞瘤细胞表现出细胞毒性作用,Butternut和Mantovana品种的特定度和持续时间.
这些提取物在体外表现出显著的抗氧化活性.
确定的主要胡卜素是β-胡卜素和各种化和环氧胡卜素.
胡卜素形状允许在C. moschata和C. maxima物种之间进行区分.

结论:

黄瓜胡卜素提取物具有细胞毒性和抗氧化特性,表明潜在的抗癌活性.
这些发现表明,南瓜胡卜素可以在癌症治疗中作为有价值的化疗辅助剂.

关键词:

这种子叫做"子".在UHPLC-MS/MS中使用.生物活跃物是生物活跃物功能性食品是一种功能性食品.神经毒性的作用.植物提取物植物提取物

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