吸入性皮质类固醇是否有效预防COVID-19肺炎的严重程度和死亡率?
Hatice Kiliç1, Emine Argüder1, Musa Civak2
1Department of Pulmonary Diseases, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Türkiye.
Tuberkuloz ve toraks
|September 14, 2024
概括
吸入性皮质类固醇的使用没有增加COVID-19患者的肺炎严重程度或死亡率. 这些发现表明,如果患有COVID-19肺炎的喘和COPD患者可以继续吸入皮质类固醇治疗.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 已知吸入性皮质类固醇 (ICS) 会增加喘和COPD患者的肺炎风险.
- ICS对COVID-19肺炎严重程度和死亡率的影响尚不清楚.
研究的目的:
- 调查吸入性皮质类固醇使用与COVID-19肺炎的严重程度和死亡率之间的关联.
- 为了确定先前存在的ICS治疗是否会影响呼吸系统疾病患者的COVID-19结果.
主要方法:
- 在一家大流行病诊所接受的COVID-19肺炎患者的回顾性观察性研究.
- 在接受ICS和未接受ICS的患者之间,肺炎严重程度和死亡率的比较.
- 单变量和多变量负二项式回归分析以确定死亡风险因素.
主要成果:
- 在使用ICS的患者 (25%) 和不使用ICS的患者 (75%) (p=0.11) 之间,肺炎严重程度没有显著差异.
- 显著的死亡风险因素包括年龄的增长,机械通风,严重的肺炎,间歇性肺部疾病和易受伤害的位置.
- ICS使用没有被确定为COVID-19肺炎死亡的风险因素.
结论:
- 吸入性皮质类固醇的使用与COVID-19肺炎的严重程度或死亡率的增加无关.
- 目前用于喘和COPD的ICS治疗可能会继续在患有COVID-19肺炎的患者中进行.
- 进一步的研究可能是有必要的,以证实这些发现在不同的群体.
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