血清阿斯素与代谢特征之间的关联分析,2型糖尿病患者的并发症,持续时间不同
Lijing Ma1, Zhengqian Wang2, Li Sun1
1Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, Shanxi, China.
在患有2型糖尿病的患者中,血清中阿斯素水平在10多年内更高. 血压和糖化血红蛋白是长期2型糖尿病的关键危险因素.
科学领域:
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
- 糖尿病研究 糖尿病研究
背景情况:
- 2型糖尿病 (T2DM) 是一个全球性的健康问题.
- 代谢失调是T2DM的一个标志.
- 阿斯普拉辛是一种新型阿迪波金,与代谢过程有关.
研究的目的:
- 调查T2DM患者血清阿司素和代谢特征之间的关联.
- 根据糖尿病持续时间来比较血清阿斯素水平.
主要方法:
- 一组436名T2DM患者被分为两组:持续时间≤5年 (n=132) 和持续时间≥10年 (n=304).
- 血清阿斯素水平从禁食血液样本中测量.
- 进行了皮尔森/斯皮尔曼相关性和多重线性回归分析.
主要成果:
- 在糖尿病持续时间≤5年的患者中,血清阿斯素与缩血压,甘油三,肌素,血清尿酸和LDL胆固醇具有积极的相关性.
- 在糖尿病持续时间≥10年的患者中,阿斯素与静脉血压,静脉血压,BMI,总胆固醇,甘油三,LDL胆固醇,肌素,血清尿酸,禁食血葡萄糖和糖化血红蛋白独立相关.
- 亚斯素也与阿兰氨基转移酶和估计的淋巴膜过率有关.
结论:
- 在T2DM患者中,血清阿斯素水平显著增加,糖尿病持续时间≥10年.
- 糖化血红蛋白,血压和估计的膜过率被确定为长期T2DM的独立风险因素.
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