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在临床前模型中,类固醇对声上皮质受伤后的急性影响

Gary Gartling¹, Lea Sayce², Zachary Zimmerman³

¹Department of Otolaryngology-Head and Neck Surgery, NYU Grossman School of Medicine, New York, New York, U.S.A.

The Laryngoscope

|September 14, 2024

概括

葡萄糖皮质体 (GCs) 通过影响表皮屏障功能和深度,影响声愈合. 虽然一些GC恢复了屏障功能,但其他诸如triamcinolone可能会减少它,从而影响治疗策略.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
声生理学声生理学
伤口愈合伤口愈合

背景情况:

葡萄糖皮质醇 (GCs) 广泛用于喉炎症.
它们对声 (VF) 表皮形态和受伤后的屏障功能的影响尚不清楚.
了解这些影响对于优化治疗策略至关重要.

研究的目的:

量化GCs对表皮形态和障碍功能在受伤的声的影响.
阐明在风湿治疗中GC作用背后的生化机制.
改进涉及GCs的喉指示的治疗方法.

主要方法:

在65只子中诱导了微损伤.
动物接受了盐水,甲甲,甲基prednisolone,或triamcinolone的内注射.
在治疗后的1,7天和60天,使用Ussing腔室和显微镜测量了脑外皮电阻 (TEER) 和上皮深度.

主要成果:

在60天后,GC治疗通常保持了与对照组相似的TEER,但与盐水相比,triamcinolone降低了TEER.
GCs没有急剧改变TEER或上皮深度,与自然愈合保持一致.
在60天后,德克萨米他和三氨增加了上皮深度;所有GC与对照组相比都增加了深度.

结论:

在受伤后60天,GC对TEER恢复和上皮质增生有不同的影响.
截然不同的GC的药理学概况可能解释了对VF愈合的差异性影响.
需要进一步的研究,以优化用于喉指示的GC使用.

关键词:

喉科喉科喉科分子生物学/声乐将治愈治疗.发声基础科学

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