在接受治疗的高血压参与者中,外周化学反射抑制了运动期间的骨肌肉血流
Ana Luiza C Sayegh1, Michael J Plunkett1, Thalia Babbage1
1Department of Physiology, Manaaki Manawa - The Centre for Heart Research, Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.
The Journal of physiology
|September 14, 2024
概括
在高血压中,过度活跃的外周化学反射限制了血液流向运动肌肉的流动. 在接受治疗的患者中,用多巴胺抑制这种反射会在休息和运动期间增加血液流动.
科学领域:
- 心血管生理学心血管生理学
- 运动生理学 运动生理学
- 高血压研究 高血压研究
背景情况:
- 高血压与自主神经系统功能的改变有关.
- 周围化学反射在心血管调节中起作用.
- 它对高血压中运动高血压的具体影响尚未完全理解.
研究的目的:
- 测试高血压中外周化学反射灵敏度增加是否抑制了运动的血液流动.
- 为了研究这种约束的同情调解.
- 为了检查抑制周围化学反射在休息和运动期间对血液流动的影响.
主要方法:
- 研究了14名接受治疗的高血压患者.
- 干预包括静脉注射盐水 (对照) 和低剂量的多巴胺来抑制周围化学反射.
- 测量是在休息状态下,在异体低氧复呼吸期间,以及在节奏手握运动期间进行的.
主要成果:
- 多巴胺增加了静止手臂动脉的血流和血管导电量,但没有改变平均血压.
- 多巴胺减弱了对低氧再呼吸的血压反应,并降低了周围化学反射灵敏度.
- 多巴胺增加了手臂动脉血液流动的增加和节奏握手运动期间的血管导电.
结论:
- 在接受治疗的高血压患者中,周围化学反射在静止状态下具有强力活性.
- 这种增强活性会抑制营养血液流向炼肌肉.
- 抑制周围化学反射可以改善高血压患者的运动高血压.
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