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Updated: Jun 24, 2026

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使用单分子纳米电路绘制内在无序蛋白质的完整整合转变动态

Dongbao Yin1,2, Ruoyao Xiong1, Zhiheng Yang1,2

  • 1Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, 292 Chengfu Road, Haidian District, Beijing 100871, P. R. China.

ACS nano
|September 14, 2024
PubMed
概括

研究人员开发了一种纳米线生物传感器,以实时跟踪单个内在无序蛋白质 (IDP). 这项技术允许研究蛋白质动态和相互作用,为新的药物发现工具铺平了道路.

关键词:
生物传感器生物传感器构造性转变 构造性转变本质上是无序的蛋白质.纳米线的使用方法单分子动力学的动力学

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相关概念视频

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...