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纤维化-4指数与高血压老年患者的认知障碍之间的关联:一个横截面研究

Hong Ding¹, Jingtao Wang¹, Shu Liu¹

¹Department of Cardiovascular Medicine, Lanzhou University Second Hospital, Lanzhou, China.

Journal of clinical hypertension (Greenwich, Conn.)

|September 14, 2024

概括

较高的纤维化-4指数 (FIB-4) 与高血压的老年人认知能力下降有关. 这种非侵入性标记可能有助于识别患肝病和认知障碍风险的个体.

科学领域:

老年学是一门学科.
神经学神经学
肝病学肝病学是一种肝病学.

背景情况:

纤维化-4指数 (FIB-4) 是经过验证的肝纤维化非侵入性生物标志物.
高血压是老年人普遍存在的并发症,也是认知能力下降的危险因素.
在高血压患者中,肝脏健康标志物与认知功能之间的关系需要进一步研究.

研究的目的:

研究老年高血压患者纤维化-4指数 (FIB-4) 与认知功能下降之间的关联.
探索FIB-4作为这一群体认知障碍的预测因子的潜力.

主要方法:

采用2011-2014年国家健康和营养检查调查 (NHANES) 的数据进行的横截面研究.
分析包括2039名年龄在60岁及以上的高血压患者.
使用多变量回归模型和平滑曲线拟合来评估FIB-4和认知性能指标 (CERAD总分,动物流利性,数字符号) 之间的相关性.

主要成果:

较高的FIB-4指数在多项措施中与较差的认知功能显著相关.
在完全调整的模型中,观察到CERAD总得分 (OR=0.72),动物流利得分 (OR=0.66) 和数字符号得分 (OR=0.36) 的统计学意义上的关联.
在FIB-4和各种认知分数之间确定了非线性关系,包括CERAD延迟回忆.

结论:

高FIB-4指数与老年高血压患者认知能力下降的患病率增加相关.
FIB-4指数可以作为一种有价值的,非侵入性的工具,用于识别患有高血压的个体,他们面临肝脏相关并发症和认知障碍的风险.
需要进一步的研究来阐明连接肝纤维化标志物和神经认知健康的潜在机制.

关键词:

在FIB-4指数.认知功能认知功能这种高血压,高血压.

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