患有前列腺癌的男性患有焦虑障碍的风险:一项全国性队列研究
Casey Crump1, Pär Stattin2, James D Brooks3
1Departments of Family and Community Medicine and of Epidemiology, The University of Texas Health Science Center, Houston, TX, USA.
JNCI cancer spectrum
|September 14, 2024
概括
患有前列腺癌 (PC) 的男性面临着显著更高的焦虑障碍风险,特别是那些患有高风险PC或接受雄激素剥夺疗法 (ADT) 的男性. 这种高风险持续长期,强调需要对焦虑症状进行警监测和及时干预.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 前列腺癌 (PC) 诊断可能会导致严重的社会心理困扰.
- 患有PC的男性长期焦虑症风险尚不清楚.
研究的目的:
- 为了研究被诊断为前列腺癌的男性焦虑障碍的长期风险.
主要方法:
- 瑞典的一项全国性队列研究包括180,189名患有PC的男性和1,801,890名对照.
- 通过全国性的健康记录来确定焦虑症.
- 考克斯回归分析调整了社会人口统计学因素和先前的精神疾病.
主要成果:
- 在780万人年的随访期间,5%的PC男性患有焦虑障碍.
- 高风险的PC与焦虑障碍的风险增加近2倍相关 (aHR=1.96).
- 抗雄激素剥夺疗法 (ADT) 与最高风险相关 (aHR=2.08);风险在10多年内仍然较高.
结论:
- 患有PC的男性,尤其是高风险病例和ADT患者,面临焦虑障碍的风险大幅增加.
- 密切监测焦虑症状对于PC患者至关重要,特别是在诊断后的早期.
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