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Updated: Jun 13, 2025

Protein Complex Affinity Capture from Cryomilled Mammalian Cells
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Protein Complex Affinity Capture from Cryomilled Mammalian Cells

Published on: December 9, 2016

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串联蛋白质复合体:从生物医学文献中提取物理蛋白质相互作用的体和方法

Farrokh Mehryary1, Katerina Nastou2, Tomoko Ohta3

  • 1TurkuNLP Group, Department of Computing, University of Turku, Turku 20014, Finland.

Bioinformatics (Oxford, England)
|September 14, 2024
PubMed
概括

我们开发了ComplexTome,这是一个新的数据集,用于识别科学文献中的蛋白质相互作用. 我们的模型准确地提取了这些相互作用,用新的生物关系数据增强了STRING数据库.

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein-Protein Interfaces02:04

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Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
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