IL-17和Th17细胞在 keloid 病原发生中的作用
David Bitterman1,2, Jennifer Y Wang1,3, Alexia Collins1,3
1Dermatology Service, Veterans Affairs New York Harbor Healthcare System - Brooklyn Campus, Brooklyn, NY, USA.
Archives of dermatological research
|September 14, 2024
概括
状体痕涉及过度的纤维细胞活动. 准T助手17 (Th17) 细胞和介质蛋白17 (IL-17) 细胞显示出新的 keloid 治疗的前景.
科学领域:
- 皮肤病学和免疫学
- 纤维化疾病研究研究 纤维化疾病研究
背景情况:
- 状体的特点是纤维细胞的过度扩散和痕组织延伸到原始损伤部位之外.
- 这些痕显著降低了患者的生活质量,导致,疼痛和心理困扰,对少数民族的影响不成比例.
- 目前,没有FDA批准的药物治疗方法可以有效地治疗状体.
研究的目的:
- 系统地审查T助手17 (Th17) 细胞和介质蛋白17 (IL-17) 在 keloid 病原发生中的作用.
- 为了确定IL-17途径作为潜在的治疗化物治疗的潜在治疗点.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 在PubMed,Embase,MEDLINE和Web of Science数据库中进行了搜索,使用与Th17细胞,IL-17和 keloids相关的术语.
- 包括13项研究,重点关注Th17细胞和IL-17在 keloid 病原发生中的作用.
主要成果:
- 在 keloids 中观察到 Th17 细胞透和 IL-17 表达的增加.
- 发现IL-17通过促进IL-6的表达来放大炎症和纤维性反应.
- IL-17通过SDF-1和HIF-1α通路调节纤维化标记物,并激活基质纤维细胞中的TGF-β/Smad通路.
结论:
- Th17细胞和IL-17在 keloid 病原发生的炎症和纤维化过程中起着重要作用.
- 准IL-17通路是一个有前途的治疗策略,可以改善 keloid 患者的治疗结果.
- 需要进一步的研究来阐明Th17细胞和IL-17的确切作用,并评估在临床研究中准这种途径的安全性和有效性.
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