直接和间接途径的条状投影神经元中的动态整体平衡,是决定相关行动选择的基础
Shunhang Tang1, Lele Cui1, Jingwei Pan2
1Institute of Neuroscience, Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Cell reports
|September 14, 2024
概括
后背条体使用直接和间接路径神经元在决策过程中平衡竞争选择. 这种平衡的动态变化引导了行动选择.
科学领域:
- 神经科学是一个神经科学.
- 决策研究 决策研究
- 状管道的功能路径
背景情况:
- 后背条体 (pDS) 对于感官引导的决策至关重要.
- 在动作选择中,直通路 (dSPNs) 和间接路 (iSPNs) 条状投影神经元之间的相互作用尚未完全理解.
研究的目的:
- 调查DSPN和iSPN如何协调,以支持决策过程中的行动选择.
- 通过体内成像来检查特定途径的神经元表示.
主要方法:
- 深层大脑二光子成像被用来监测单个神经元和人群活动.
- 在听觉引导的决策任务中记录了神经元活动.
主要成果:
- 大多数pDS投射神经元编码选择信息,dSPN和iSPN都包含代表竞争选择的子群体.
- 观察到dSPN和iSPN组合之间的平衡,在决策期间有动态转变.
- 与iSPN相比,dSPN对逆向选择的偏好更强,由神经元间协作和人口轨迹分歧证明.
结论:
- 一个平衡转移模型解释了协调的直接和间接的条形状路径如何促进行动选择.
- 路径活动的动态转变对于决策过程至关重要.
相关概念视频
Indirect Motor Pathways
1.4K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.4K
Direct Motor Pathways
1.8K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
1.8K
Diencephalon: Thalamus and Information Relay
1.5K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.5K
Reason and Intuition
6.4K
The human brain processes information for decision-making using one of two routes: an intuitive system and a rational system (Epstein, 1994; popularized by Kahneman, 2011 as System 1 and System 2, respectively). The intuitive system is quick, impulsive, and operates with minimal effort, relying on emotions or habits to provide cues for what to do next, while the rational system is logical, analytical, deliberate, and methodical. Research in neuropsychology suggests that the...
6.4K


