一种简单的方法来制造一种具有双重血静效应的血栓固定复合海绵,用于控制急性出血
Dandan Hou1, Yansen Wang1, Liya Qi1
1SINOPEC Key Laboratory of Research and Application of Medical and Hygienic Materials, SINOPEC (Beijing) Research Institute of Chemical Industry Co., Ltd., Beijing 100013, China.
Biomaterials advances
|September 14, 2024
概括
这项研究引入了由细菌纤维素和聚乙烯醇制成的新型双作用静血海绵 (TCP),有效控制严重出血. 这些先进的海绵加速血液凝结和吸收,为关键情况下提供卓越的静血效率.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 手术创新 在外科创新.
背景情况:
- 失控出血是创伤和手术中死亡的主要原因.
- 现有的静血海绵往往缺乏足够的凝固能力或双重机制.
- 需要先进的血静止剂,提高疗效和生物相容性.
研究的目的:
- 开发具有双重静血效应的新型静血复合海绵.
- 为了创建一个细菌纤维素/聚乙醇 (BC/PVA) 子与固定血栓 (TCP).
- 评估开发的TCP海绵的体外和体内静血性能.
主要方法:
- 用于将细菌纤维素纳入聚乙醇基质的BC/PVA (CP) 海绵的制造.
- 通过物理吸附和共价结合将血栓素固定在CP海绵上,以创建TCP海绵.
- 评估结构性,吸收性,生物相容性和静血性质 (体外和体内).
主要成果:
- TCP海绵表现出高度多孔的结构,优秀的液体吸收和低血解.
- 在体外试验显示出强烈的凝血,快速的血液吸收和凝血级联的激活.
- 在体内评估证实了高血静效率和多方面的血静效应在管理严重出血.
结论:
- 开发的携带血栓素的CP (TCP) 复合海绵显示出作为先进的血液静止剂的巨大潜力.
- TCP海绵提供双重静血机制,优越的吸收能力和生物相容性,用于治疗急性和严重出血.
- 这项创新为改善复杂的手术和创伤场景的结果提供了一个有希望的解决方案.
相关概念视频
01:05Introduction to Hemostasis
6.6K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
6.6K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
652
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
652
01:16Clot Retraction and Fibrinolysis
4.9K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
4.9K
01:20Extrinsic and Intrinsic Pathways of Hemostasis
6.5K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
6.5K
01:22Formation of the Platelet Plug
5.3K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
5.3K
01:09Coagulation
5.6K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
5.6K