神经长期COVID:疲劳,自律障碍,抑郁和主观记忆问题的关联
Giovanni Furlanis1, Alex Buoite Stella1, Giovanna Torresin1
1Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste - ASUGI, University of Trieste, Strada di Fiume, Trieste 447-34149, Italy.
Clinical neurology and neurosurgery
|September 14, 2024
概括
长期COVID疲劳与自主功能障碍,认知问题和抑郁症有关. 在急性和长期COVID期间较高的症状负担预测疲劳严重程度.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 长期COVID是一种复杂的多系统疾病,具有多种症状.
- 疲劳是长期COVID的最常见症状,但缺乏标准化的定义.
- 包括疲劳在内的神经表现在长期COVID患者中是一个重大问题.
研究的目的:
- 为了研究神经长期COVID的神经系统的神经认知和身体症状.
- 为了检查疲劳,自主功能障碍,认知障碍 (大脑雾) 和抑郁症状之间的关系.
- 为了确定长期COVID患者疲劳的预测因素.
主要方法:
- 来自神经长期COVID诊所的141名患者完成了自我报告问卷.
- 经过验证的尺度评估了疲劳 (FSS),自主功能障碍 (COMPASS-31),认知障碍 (PRMQ) 和抑郁症 (BDI).
- 患者被分为疲劳 (FSS>4.67) 或非疲劳进行比较分析.
主要成果:
- 疲劳的患者报告自主功能障碍 (COMPASS-31),抑郁症 (BDI) 和认知障碍 (PRMQ) 的得分显著更高.
- 多变量回归在急性和长期COVID阶段确定了较高的症状负担作为疲劳的预测因素.
- 自主功能障碍 (COMPASS-31 > 16) 和抑郁症 (BDI > 15) 是疲劳的重要预测因素.
结论:
- 这项研究确立了疲劳,自主功能障碍和长期COVID中的抑郁症之间的显著关联.
- 在急性感染和长期COVID阶段的症状负担与持续的疲劳有关.
- 这些发现强调了长期COVID中神经和心理症状的相互联系.
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