与伊特拉科纳相关的充血性心力衰竭在一个患有帕拉科西迪奥伊多米科西斯的患者身上
Hugo Haran Souza Andrade1, Isabel Cunha Santos1, Roger Lopes Batista1
1Universidade Federal do Triângulo Mineiro, Departamento de Medicina Interna, Unidade de Doenças Infecciosas, Uberaba, MG, Brazil.
概括
伊特拉科纳 (ITZ),用于真菌感染,如帕拉科西迪奥伊多米科斯 (PCM),可以导致心力衰竭 (CHF). 这一案例突出了ITZ诱导的CHF,该CHF在药物停用后消失,强调了对心脏监测的需要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 伊特拉科纳 (ITZ) 是一种关键的抗真菌药物,用于治疗真菌菌病,包括帕拉科西迪奥多米科斯 (PCM).
- 与ITZ相关的不良事件包括毒性和严重的疾病,如充血性心力衰竭 (CHF).
研究的目的:
- 介绍一个诊断为PCM的患者的病例研究,该患者在ITZ治疗后发展出CHF.
- 为了解ITZ诱导的心脏毒性做出贡献.
主要方法:
- 一名患有慢性成人PCM的50岁男性患者每天两次接受ITZ200mg治疗.
- 用临床表现,心电图 (ECG) 和心声图 (回声) 来评估心脏功能.
- 终止了ITZ,并用trimethoprim-sulfamethoxazole取而代之.
主要成果:
- 这位患者在两个月的ITZ治疗后出现了急性心脏不全症,之前没有心脏病史.
- 电脑心电图显示了心室再极化变化和左前上部分裂块.
- 心声图显示左心室缩功能略有下降,排泄率为51%.
结论:
- 患者的慢性心血管疾病症状在停止ITZ后一周内消失.
- 虽然很少见,但ITZ诱导的CHF是一种潜在的不良影响,通常取决于剂量,并在药物停止后可逆.
- ITZ可能会产生负面的内效应,并可能导致线粒体功能障碍,尽管机制需要进一步阐明.
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