14-3-3εS20-OGT,OGT

Sheng Yan1, Kemeng Yuan1, Xinyi Yao2

  • 1Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing, China.

PubMed
概括

检查点酶1 (Chk1) 在细胞分裂过程中调节O结合的N-乙糖胺 (O-GlcNAc) 转移酶 (OGT) 的稳定性和功能. 一种子宫癌突变 (R17C) 破坏了OGT酸化,导致细胞动力学缺陷并抑制了子宫癌的进展.

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