甲状腺功能障碍症保持免疫球蛋白水平,但在早期哺乳期减少牛奶脂肪和CD11b/c+细胞
María Belén Sánchez1, María Cecilia Michel Lara2, Flavia Judith Neira3
1Instituto de Medicina y Biología Experimental de Cuyo CONICET, Universidad Nacional de Cuyo, Mendoza, Argentina; Facultad de Ciencias Veterinarias y Ambientales, Universidad Juan Agustín Maza, Mendoza, Argentina.
Molecular and cellular endocrinology
|September 14, 2024
概括
孕产妇甲状腺功能障碍会对后代的发育产生负面影响,并改变牛奶的成分. 这项研究揭示了乳腺结构和牛奶中的免疫因素的变化,影响了幼的生长和健康.
科学领域:
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺激素对于乳腺功能和哺乳期至关重要.
- 怀孕期间甲状腺功能障碍会对母亲的健康和后代的发育产生负面影响.
- 孕产妇甲状腺功能障碍对母乳成分的影响,特别是免疫因素,仍然不清楚.
研究的目的:
- 研究母亲甲状腺功能障碍对乳腺形态,牛奶质量和早期哺乳期免疫学参数的影响.
- 评估甲状腺功能障碍对后代发育和生理参数的影响.
主要方法:
- 在交配前和整个怀孕期间,雌性Wistar大鼠被诱导过高甲状腺症 (T4注射).
- 乳腺,血清和牛奶样本是在哺乳期第二天采集的.
- 分析包括幼犬形态测量,血清生物化学,乳腺组织学,牛奶成分和免疫细胞概况.
主要成果:
- 甲状腺功能的母婴体重,长度和头部周长都减小了,血清葡萄糖和白蛋白也发生了变化.
- 乳腺显示结构变化,包括膜面积和上皮延长的减少,以及TRβ1RNA表达的减少.
- 甲状腺功能高的牛奶的热量值较低,脂肪度较低,免疫细胞数量发生变化 (增加CD45+,CD3+;减少CD11b/c+).
结论:
- 孕产妇甲状腺功能过高会对乳腺的发育和功能产生不利影响.
- 甲状腺功能障碍会扰乱后代的生长,并改变牛奶的生物化学和免疫学特征.
- 甲状腺激素的状况对孕产妇和新生儿的健康至关重要,影响牛奶免疫成分和早期发育.
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