与肠道相关的分子作为不补偿性肝硬化患者的潜在生物标志物
Camila Marques de Alcântara Barreto1, Eliane Almeida do Valle2, Jessica Pronestino de Lima Moreira3
1Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil; Bonsucesso Federal Hospital, Rio de Janeiro, 20950-003, Brazil.
Annals of hepatology
|September 14, 2024
概括
血清中calprotectin和zonulin水平显示为不侵袭性预后生物标志物,有助于预测不良结果和死亡率.
科学领域:
- 肝病学和胃肠道学
- 生物标志物发现发现
- 临床预后 临床预后
背景情况:
- 微生物转移是已知的肝硬化进展和相关并发症的驱动因素.
- 确定可靠的预后生物标志物对于管理不补偿性肝硬化患者至关重要.
研究的目的:
- 研究肠道透性和微生物转位标记物作为未补偿性肝硬化病的预后生物标记物的潜力.
- 评估这些标志物与临床结果的关联,包括死亡率和并发症.
主要方法:
- 对91名患有不补偿性肝硬化病的住院患者的前性评估.
- 在入院时测量血清1,3β-d-葡萄糖,佐努林,calprotectin和脂多糖结合蛋白.
- 评估肝功能,住院并发症,死亡率和12个月生存率.
主要成果:
- 血清佐努林与住院并发症 (急性损伤) 和复合结局相关.
- 血清calprotectin与所有评估结果有关,除了12个月死亡率.
- 血清1,3β-葡萄糖与末期肝病模型和Child-Pugh分数呈正相关性.
结论:
- 血清中calprotectin和zonulin水平正在成为有价值的非侵入性预后生物标志物.
- 这些生物标志物可以帮助识别患有不补偿性肝硬化症的患者,他们面临更高的不良结果风险.
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