在基于人口的Telemark研究中,职业暴露和新发喘:为期5年的随访研究
Nikola Zivadinovic1,2, Keson Jaoiun3, Geir Klepaker4
1Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, Norway nikozi@sthf.no.
BMJ open
|September 14, 2024
概括
职业暴露于蒸气,气体,尘埃和烟雾 (VGDF) 与新发性喘有关,其中17%的人口可归因于喘. 减少VGDF暴露可以预防喘的发展.
科学领域:
- 职业健康 职业健康 职业健康
- 呼吸系统医学 呼吸系统医学
- 流行病学 流行病学
背景情况:
- 工作场所的暴露越来越被认为是导致呼吸系统疾病的因素.
- 喘仍然是一个重要的公共卫生问题,职业因素起着显著的作用.
研究的目的:
- 为了估计工作人口中新发喘的发病率.
- 评估职业暴露 (VGDF,菌,潮湿,寒冷) 与新发喘之间的关联.
- 为了确定VGDF暴露的人口归因分数 (PAF).
主要方法:
- 一项基于人口的纵向研究跟踪了7120名年龄在16-55岁之间的参与者,持续了5年.
- 新发性喘与自我报告的职业暴露和职业暴露矩阵 (N-JEM) 数据一起进行了评估.
- 后勤回归和特定的统计指令被用于分析.
主要成果:
- 新发喘的发病率密度为每1000人年7.5,确诊266例.
- 长期暴露于VGDF显示与新发喘有显著的关联 (OR 1.49),随频率增加而增加.
- 对于暴露在菌,潮湿损伤和寒冷环境中也发现了显著的关联.
结论:
- 职业暴露,包括VGDF,菌和水分,与新发喘有显著的相关性.
- 对于VGDF暴露的17%的PAF强调了与工作相关的喘的重大负担.
- 减少职业VGDF暴露频率是预防喘的一个潜在策略.
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