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从谷物中获得的5-heptadecyresorcinol的修饰和体外吸收,使用消化和使用室内模型

Lei Jiang¹, Xiaofang Chen², Kuiliang Zhang¹

¹State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.

Food research international (Ottawa, Ont.)

|September 14, 2024

概括

来自triticale分枝的5-Heptadecylresorcinol (AR-C17) 显示了与奎尔塞丁和β-cyclodextrin的增强吸收. 这项研究优化了AR-C17的提取和生物可用性,用于更广泛的应用.

科学领域:

食品科学与技术食品科学与技术
营养生物化学营养生物化学
自然产品化学自然产品化学

背景情况:

5-Heptadecylresorcinol (AR-C17),一种在谷物中发现的强效基基,具有显著的生理益处.
自然丰度较低,净化挑战以及对其消化和生物可用性的有限理解阻碍了AR-C17的应用.
优化AR-C17的提取和吸收对于利用其健康潜力至关重要.

研究的目的:

系统评估AR-C17提取和生物可用性的加工技术.
使用体外模型研究AR-C17的消化和吸收特性.
通过协同作用剂和封装来增强AR-C17的稳定性和吸收.

主要方法:

使用Saccharomyces cerevisiae用超声波辅助AR-C17提取的三角的固态发酵.
在体外消化模型评估AR-C17在十二指肠和十足肠中的吸收.
用β-cyclopodextrin封装来保护AR-C17免受酸性分解,并增强稳定性.
评估了氨酸对AR-C17吸收的协同效应.

主要成果:

超声波辅助发酵的最大AR-C17含量为57.6μg/g,来自三树枝.
AR-C17的吸收主要发生在十二指肠和十足肠中,与瑞丁结合时增加2.1倍.
在体外,β-cyclopodextrin封装使AR-C17的保留率提高到96%,防止在酸性条件下降解.
一个1:1的AR-C17和奎尔丁混合物,封装在β-cyclodextrin中,最大限度地使表面吸收达到19.8%.

结论:

优化的固态发酵和超声波辅助显著增加了三树枝的AR-C17产量.
奎尔素作为一种强大的协同作用剂,大大提高了AR-C17的生物可用性.
β-环极素封装有效地保护AR-C17,改善其稳定性和吸收性,为改善饮食应用铺平道路.

关键词:

在 AR-C1717 中.显然的吸收吸收.嵌入式嵌入式奎尔丁 (Quercetin) 是一种青素.固体发酵是一种固体发酵.

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