在干眼病和良性基本白发作中对上眼压力和眼睛表面参数进行比较:一个横截面研究
Guohong Zhao1, Jingyi Wang1, Qian Ma1
1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China.
概括
干眼病 (DED) 与同时存在的良性基本血栓 (BEB) 与单独的DED相比,显示了较高的上眼压力和改变的眼模式. 这些因素可能表明DED患者患有BEB的风险.
科学领域:
- 眼科医生 眼科 眼科
- 眼睛表面疾病 眼睛表面疾病
- 神经眼科神经眼科
背景情况:
- 干眼病 (DED) 和良性基本血栓 (BEB) 是常见的眼睛表面疾病.
- DED和BEB的共存带来了独特的诊断和治疗挑战.
- 了解DED和BEB之间的相互作用对于有效管理至关重要.
研究的目的:
- 为了比较DED患者与与BEB共存的DED患者的上眼压力 (UEP) 和眼表面参数.
- 确定可以区分DED和BEB的参数.
- 探索与BEB一起发生DED的潜在风险因素.
主要方法:
- 参与者被诊断为DED或DED与BEB.
- 对所有参与者来说,确定了眼部表面疾病指数 (OSDI).
- 上眼压力 (UEP) 使用专用设备进行测量.
- 进行了眼睛表面检查和眼模式分析.
- 统计分析包括独立的t测试,曼-惠特尼U测试和后勤回归.
主要成果:
- 与DED组相比,BEB组表现出更高的UEP (101.9 vs 88.4 mN) 和更高的部分闪率.
- 患有BEB的患者总眼次数较少,Meibum表达能力较低,Meibum质量也较低.
- 后勤回归确定了较高的UEP,较低的部分眼率和较差的meibum表达性作为DED中BEB的显著预测因素.
结论:
- 尽管OSDI得分相似,但DED与BEB在UEP和眼表面参数方面与DED单独显著不同.
- 较高的UEP,较低的部分眼率和较差的梅布姆表达性与DED患者的BEB有关.
- 这些参数可以作为指标来识别患有DED的个体的BEB风险.
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