Orientia tsutsugamushi Ank5促进NLRC5的细胞质保留和降解,以抑制MHC I类表达

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Haley E Adcox1,2, Jason R Hunt1, Paige E Allen1

  • 1Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, VA, USA.

Nature communications
|September 14, 2024
PubMed
概括

Orientia tsutsugamushi 细菌使用 Ank5 效应蛋白来降解 NLRC5,这是MHC I 类表达的关键调节者. 这种细菌策略有助于病原体通过减少表面MHC I类分子来逃避免疫检测.

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