在工作记忆期间,前额叶皮质的动态层特定处理
Jonas Karolis Degutis1,2,3, Denis Chaimow4, Daniel Haenelt4
1Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. j.karolis.degutis@maxplanckschools.de.
Communications biology
|September 14, 2024
概括
背侧前额皮质 (dlPFC) 的表面层优先处理工作记忆 (WM) 负载,在任务期间进行动态编码. 这与表面和深层在运动反应中的非差异性参与形成鲜明对比.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 神经成像是一种神经成像.
背景情况:
- 脊侧前额叶皮层 (dlPFC) 对工作记忆 (WM) 是至关重要的.
- 在WM期间,dlPFC内的特定细胞架构层的功能作用仍然不太清楚.
- 了解层状电路是解读dlPFC对认知的贡献的关键.
研究的目的:
- 在工作记忆任务期间调查人类dlPFC中的特定层次活动.
- 检查WM负载和运动反应如何调节不同dlPFC皮质层中的活动.
- 阐明dlPFC在WM中的功能层状组织.
主要方法:
- 使用了超高分辨率的功能磁共振成像 (fMRI).
- 参与者执行了一个延迟匹配到样本的任务来评估WM.
- 分析了与WM负载和电机需求相关的层特定的BOLD响应.
主要成果:
- 表面的dlPFC层在延迟和检索过程中对WM负载的反应显示出优先激活.
- 在表面层编码WM负载的多变量模式显示了跨任务阶段的动态变化.
- 表面和深层dlPFC层都同样参与了运动反应的执行.
结论:
- 结果揭示了 dlPFC 内部用于工作记忆处理的板状特异性功能组织.
- 表面层在WM负载编码中发挥着独特的作用,具有动态表示.
- 这些发现挑战了先前关于 dlPFC 内偏好的深层参与运动反应的概念.
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