前列腺癌放射治疗后的射精功能:系统性审查和元分析
Umar Ghaffar1, Behzad Abbasi1, Kevin D Li1,2
1Department of Urology, University of California San Francisco, San Francisco, CA, USA.
Prostate cancer and prostatic diseases
|September 14, 2024
概括
前列腺辐射显著影响男性射精,18%的人没有射精,85%的人报告射精量减少 (EV). 患者应被告知这些潜在的副作用.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 放射学 放射学是一门学科.
背景情况:
- 关于前列腺辐射对男性射精功能影响的数据有限.
- 前列腺放射治疗是前列腺癌的常见治疗方法.
研究的目的:
- 系统地审查并对前列腺放射治疗后男性的射精结果进行元分析.
- 量化无精射率,射精量 (EV),射精不适 (EjD) 和射精功能得分 (EFS) 在放射后的变化.
主要方法:
- 在PubMed,Embase和Web of Science进行了系统的文献搜索.
- 包括17项涉及2156名患者的观察性研究.
- 用逆方差和随机效应模型来计算聚合比例以评估结果.
主要成果:
- 经历无精射的患者的综合比例为18% (95% CI,11-36%).
- 在85% (95% CI,81-89%) 的患者中观察到射精体积 (EV) 的显著减少.
- 射精不适 (EjD) 影响了24% (95% CI,16-35%),五项研究报告了射精功能得分 (EFS) 的下降.
结论:
- 前列腺放射治疗可以导致男性射精功能发生实质性变化,包括射精缺失,减少EV和EjD.
- 在开始治疗之前,建议患者了解这些潜在的不良影响至关重要.
- 可能需要进一步的研究来探索这些副作用的缓解策略.
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