益生菌相关的Zeger治疗对牙健康的微生物学和临床影响:一项随机对照临床试验
1State Key laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, No.14, 3Rd Section Of Ren Min Nan Rd., Chengdu, 610041, Sichuan, China.
BMC oral health
|September 14, 2024
概括
基于库米斯的Zeger疗法,通过增加有益细菌和减少有害细菌,增强了成年人患有牙炎的口腔微生物群多样性. 虽然微生物学变化显著,但在这项研究中没有观察到牙炎的临床改善.
科学领域:
- 口腔微生物学 口腔微生物学
- 微生物群多样性 微生物群多样性
- 牙健康研究 牙健康研究
背景情况:
- 牙炎影响了相当一部分成年人群,需要有效的治疗干预措施.
- 了解口腔中的微生物变化对于开发针对牙健康的向治疗至关重要.
研究的目的:
- 评估Zeger疗法 (koumiss) 对成年人牙炎牙健康的微生物学和临床影响.
- 评估米的消费对上微生物组的组成和多样性的影响.
主要方法:
- 一个单盲随机对照试验,涉及24名被诊断患有牙炎的成年人.
- 参与者接受了supragingival缩放,然后随机分配到实验组 (koumiss,n=12) 或对照组 (n=12).
- 微生物学和临床评估在基线和每天食用库米斯4周后进行.
主要成果:
- 实验小组显示微生物多样性的显著增加 (p<0.05),Gram阳性和有益的口腔微生物 (例如,Rothia,Corynebacterium) 的增加和Gram阴性和牙周病相关微生物 (例如,Porphyromonas,Fusobacterium) 的减少.
- 对照组在微生物多样性上没有显著变化 (p>0.05).
- 库米斯和对照组之间没有观察到牙炎临床参数的统计学上显著差异 (p>0.05).
结论:
- 泽格尔疗法 (koumiss) 有效地促进了成年人患有牙炎的牙微生物群多样性.
- 该疗法增加了有益的口腔菌群,并减少了有害细菌,这表明了未来牙炎管理的潜力.
- 需要进一步的研究来探索 koumiss 作为口腔保健方法的临床疗效和长期益处.
相关概念视频
01:22Probiotics
296
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
296
01:27The Oral Microbiota
90
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
90
01:28Development of the Oral Microbiota
65
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
65