虹膜素通过调节脏AMPK-Rac1通路来减轻对盐敏感的高血压
Jie Mao1, Xiaocui Zhang1, Chunxiang Wang2
1Department of Nephrology, Chongqing Fuling Hospital, School of Medicine, Chongqing University, Chongqing, China.
Clinical and experimental hypertension (New York, N.Y. : 1993)
|September 15, 2024
概括
虹膜素治疗通过激活AMPK和调节RAC1-MR通路,降低了大鼠对盐敏感的高血压. 这种myokine为管理与盐摄入相关的高血压提供了潜在的治疗策略.
科学领域:
- 内分泌学 在内分泌学.
- 心血管生理学心血管生理学
- 脏生理学 脏生理学
背景情况:
- 素,一种肌素,以其对心血管疾病的保护作用而闻名.
- 素在减轻对盐敏感高血压方面的作用及其潜在机制在很大程度上仍未被探索.
研究的目的:
- 在大鼠模型中研究虹膜素在减轻盐敏感高血压方面的疗效.
- 在高盐摄入的背景下,阐明素影响功能和血压调节的分子机制.
主要方法:
- 雄性达尔盐耐药 (DSR) 和达尔盐敏感 (DSS) 的老鼠接受了高盐饮食 (8% NaCl) 8 周.
- 在高盐饮食期间,老鼠接受了内注射虹膜素或对照溶液.
- 评估了功能,血压和关键信号分子 (p-AMPKα,RAC1,矿物皮质皮质受体) 的表达.
主要成果:
- 与DSR大鼠相比,DSS大鼠表现出较高的缩血压 (SBP),受损的自然尿液和尿液,以及功能障碍.
- 在DSS大鼠中,高盐摄入导致脏p-AMPKα的下调和脏RAC1和核MR的上调.
- 虹膜素干预显著增加了的p-AMPKα和降低了的RAC1-MR信号,改善了的分泌和功能,并减少了DSS大鼠中的SBP.
- 活体研究证实了依赖AMPK激活的细胞中对RAC1和核MR的素作用.
结论:
- 在老鼠中,Irisin的使用有效降低了对盐敏感的高血压.
- 素的抗高血压作用是由AMPK的激活介导的,AMPK随后调节RAC1-MR信号传递.
- 虹膜代表了对盐敏感高血压的有希望的治疗候选者.
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