在清醒和麻醉的小鼠大脑中,神经元,代谢和血液动力学信号之间的时空关系
Xiaodan Wang1, Jonah A Padawer-Curry2, Annie R Bice3
1Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in Saint Louis, St. Louis, MO 63130, USA.
Cell reports
|September 15, 2024
概括
神经血管合 (NVC) 和神经代谢合 (NMC) 影响大脑成像. 氨酸/西拉麻醉改变NVC比NMC更多,影响代谢连接体不同于血液动力学措施.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 系统神经科学 系统神经科学
背景情况:
- 神经血管合 (NVC) 和神经代谢合 (NMC) 是功能神经成像技术 (如fMRI和PET) 的基础.
- 虽然神经元活动往往与血液中的氧气和代谢变化相关,但这种合可能是可变的.
- 改变NMC/NVC对大脑网络组织的影响,特别是静止状态功能连接 (RSFC),仍然不清楚.
研究的目的:
- 调查神经血管和神经代谢合动态如何影响静止状态功能连接 (RSFC) 的措施.
- 为了比较胺/西拉麻醉对小鼠皮层NMC和NVC的影响.
- 为了确定麻醉诱导的NMC/NVC变化是否会改变代谢与血液动力学RSFC.
主要方法:
- 在Thy1-jRGECO1a小鼠中利用广场光学成像,同时绘制皮质活动,黄蛋白自 (氧化代谢) 和血液动力活动的地图.
- 记录了在清醒和胺/西拉麻醉期间的自发大脑活动.
- 分析了自发动态,以评估与RSFC一致的模式,并量化了相对于神经元活动的NMC/NVC.
主要成果:
- 在清醒和麻醉期间自发的大脑活动显示了所有测量对比度的RSFC特征模式.
- 神经血管和神经代谢合在皮质中相对于激发性神经元活动而有所不同.
- 胺/西拉麻醉显著改变了NVC,但对NMC的影响不那么明显.
- 麻醉诱导的变化影响了基于代谢的连接体,而不是基于血液动力学的RSFC测量.
- 尽管由于麻醉而改变了NMC/NVC时间,但RSFC的整体结构基本没有改变.
结论:
- 神经血管和神经代谢合表现出空间变异性,并且受到胺/西拉麻醉的差异影响.
- 麻醉引起的合变化主要影响大脑连接的代谢指标,对血液动力RSFC的影响较小.
- 休息状态功能连接的基本结构对于神经血管和神经代谢合时间的麻醉相关变化是强大的.
相关概念视频
01:12Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
02:47The Synapse
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
01:09Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
01:28Electrical Synapses
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
01:25Overview of Synapses
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
01:28Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...