患有子宫内膜激增症的不孕妇女的治疗结果,她们正在接受第一次试管婴儿/ICSI周期:一项匹配对的研究
Jing Yang1, Mingmei Lin2, Di Mao3
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China; Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Shanxi, China.
European journal of obstetrics, gynecology, and reproductive biology
|September 15, 2024
概括
辅助生殖对于子宫内膜增生 (EH) 缓解的患者是有效的. 生产的关键因素包括母亲的年龄,BMI和子宫内膜厚度,指导干预策略.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 妇科瘤学 妇科瘤学
背景情况:
- 子宫内膜增生 (EH) 可以影响生育能力和生殖结果.
- 辅助生殖技术 (ART) 之后的保守管理是希望怀孕的EH患者的潜在治疗途径.
研究的目的:
- 分析经过IVF/ICSI的EH患者的临床特征,卵巢刺激和怀孕结果.
- 确定影响该患者群体活产率的因素.
主要方法:
- 一项匹配对的研究包括了经过第一个IVF/ICSI周期的完全缓解的EH患者.
- 根据控制卵巢刺激分析的年龄,患者与对照者 (正常子宫内膜) 匹配1: 2.
主要成果:
- 研究小组 (n=263) 在第一个IVF/ICSI周期中实现了48.67%的怀孕率和34.98%的活产率.
- 母亲年龄 (≥35岁),BMI (≥28 kg/m2) 和子宫内膜厚度 (≥10 mm) 显著影响了活产的结果.
- 先进的母亲年龄和更高的BMI是不利的因素,而足够的子宫内膜厚度是有利的.
结论:
- 试管婴儿 (IVF) 和细胞内精子注射 (ICSI) 对缓解的EH患者是有效的.
- 建议优化体重,避免不必要的宫内手术,及时进行ART干预,以改善结果.
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