皮下脂肪组织的放射密度:一种新兴的严重COVID-19风险因素
Daniela M H Padilha1, Maria C S Mendes2, Maria E S Takahashi3
1Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, University of Campinas, Campinas SP, Brazil; Nestlé Health Science, Lausanne, Switzerland.
Nutrition (Burbank, Los Angeles County, Calif.)
|September 15, 2024
概括
在COVID-19患者中,皮下脂肪组织高放射密度 (SATR) 与死亡率增加和严重并发症有关. 这一发现突出了SATR作为预测COVID-19严重程度的潜在生物标志物.
科学领域:
- 医学成像医学成像
- 脂肪组织生物学 脂肪组织生物学
- 传染病研究传染病研究.
背景情况:
- 脂肪组织的特征,如放射密度和代谢活性,可能会影响COVID-19患者的结果.
- 以前的研究表明,身体组成和传染病严重程度之间存在联系.
研究的目的:
- 研究脂肪组织辐射密度和代谢活动与住院COVID-19患者的临床结果之间的关联.
- 为了确定脂肪组织特征是否可以作为COVID-19的预后生物标志物.
主要方法:
- 两组COVID-19患者队伍的回顾性分析.
- 计算机断层扫描 (CT) 用于评估皮下脂肪组织放射密度 (SATR) 和内脏脂肪组织放射密度.
- 用于测量脂肪组织代谢活动的FDG-PET/CT.
- 回归分析检查了与死亡率,住院时间,通风需求和并发症的关联.
主要成果:
- 较高的SATR独立地与增加的死亡风险相关 (OR:2.70;P = 0.033).
- 升高的SATR与更长的住院时间相关 (P < 0.001),增加机械通风的需要 (P = 0.007),并发症的发生率更高,包括急性损伤,二次感染,休克和肺栓塞.
- SATR显示了皮下脂肪组织葡萄糖吸收的正相关性 (ρ = 0.52) 和丁水平的负相关性 (ρ = -0.48).
结论:
- 在COVID-19诊断时SATR升高是疾病严重程度和不良结果的重要预测因素.
- SATR成为一种潜在的预后生物标志物,用于包括COVID-19在内的急性和慢性炎症疾病.
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