与野火相关的PM2.5和因特定原因癌症死亡率
Yuan Gao1, Wenzhong Huang1, Zhihu Xu1
1School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Ecotoxicology and environmental safety
|September 15, 2024
概括
野火的烟雾 在野火的烟雾
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 野火对公众健康和社会产生重大影响.
- 有限的基于人口的队列研究存在于野火PM2.5和癌症死亡率.
- 了解这些风险对于公共卫生干预至关重要.
研究的目的:
- 调查与野火相关的PM2.5暴露与英国人口癌症特异性死亡率之间的联系.
- 为了确定易受伤害的子组,增加了野火烟雾暴露的风险.
主要方法:
- 利用了来自492,394名参与者 (38-73岁) 的英国生物库数据.
- 评估了使用化学运输和机器学习模型在三年内累积的野火PM2.5暴露.
- 采用时间变化的考克斯回归和子组分析来探索关联和变量.
主要成果:
- 3年累计PM2.5暴露的10μg/m3增加与总癌症 (0.4%),肺癌 (1.1%) 和唇部,口腔和喉 (LOP) 癌症 (2.7%) 的更高风险相关.
- 退休人员对与野火PM2.5.5相关的肺癌风险的脆弱性更高.
- 即使是低水平的野火PM2.5暴露也与癌症死亡率的增加有关.
结论:
- 与野火相关的PM2.5暴露与癌症特异性死亡风险增加有关,包括肺癌和LOP癌症.
- 强调需要采取野火预防和控制措施,以减轻对公共卫生的影响.
- 将退休人员确定为需要有针对性的关注的潜在脆弱群体.
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