CPP-Febisgly复合物的结构变化和体外生物可访问性:依赖于铁负荷
Ruixue Wang1, Huasong Bai2, Tong Liu2
1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Food chemistry
|September 15, 2024
概括
素酸 (CPP) 通过增强铁糖酸盐 (FebisGly) 的生物可访问性和形成稳定的化铁结构,显著改善铁补充. 这种新的策略可以减少胃部刺激,改善抗氧化活性.
科学领域:
- 营养科学 营养科学
- 生物化学 生化学
- 材料科学 材料科学 材料科学
背景情况:
- 缺铁性贫血仍然是一个全球性的健康问题.
- 传统的铁补充剂往往受到生物可用性差和胃肠道副作用的影响.
- 众所周知,素脂 (CPP) 可以增强矿物质的吸收.
研究的目的:
- 为了研究CPP和铁 bisglycinate (FebisGly) 对补充铁的协同作用.
- 评估CPP对FebisGly体外生物可访问性,结构性质和抗氧化活性的影响.
- 探索CPP在克服铁吸收抑制剂中的作用.
主要方法:
- 在不同的CPP:FebisGly比率 (1:20, 1:10, 1:5 w/w) 中体外评估铁的生物可获得性.
- 分析结构变化使用技术,如循环二元化 (CD) 光谱.
- 颗粒大小分布 (PSD) 和风学分析,以评估化铁的形成.
- 对抗氧化剂活性和与吸收抑制剂 (植物酸,酸,纤维素) 竞争的评估.
主要成果:
- CPP提高了FebisGly的生物可访问性,达到68.72%.
- CPP增加了β-片含量,表明稳定的二次结构形成和合铁.
- 观察到均的PSD和增强的粘弹性,表明铁复合物的稳定性得到改善.
- CPP延长了胃排空时间,减少了胃刺激,并超过了铁的吸收抑制剂.
结论:
- CPP显著提高了铁二糖酸盐的生物可访问性和稳定性.
- 化机制涉及CPP的碳素和氨基群,改善抗氧化特性.
- 这项研究为开发具有更高效率和耐受性的先进铁补充策略提供了基础.
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