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脑小血管疾病中的渐进性大脑结构异常,通过使用因果网络分析的MRI成像来评估

Ronghua Mu¹, Xiaoyan Qin¹, Wei Zheng¹

¹Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, 541004 Guilin, China.

NeuroImage. Clinical

|September 15, 2024

概括

大脑小血管疾病 (CSVD) 导致灰质体积损失,从右海马开始,随着认知能力下降而扩散. 右海马驱动CSVD进展中的这些结构变化.

科学领域:

神经成像是一种神经成像.
神经学神经学
神经退行发生神经退行.

背景情况:

大脑小血管疾病 (CSVD) 涉及大脑微循环障碍和神经退行,导致结构异常.
在CSVD中,特别是认知障碍时,结构变化的渐进模式尚不清楚.

研究的目的:

在CSVD患者中研究灰质体积 (GMV) 的渐进结构变化.
根据认知障碍的严重程度来确定GMV变化的模式.
探索CSVD进展中大脑区域之间的因果关系.

主要方法:

招募了121名CSVD患者和104名健康对照 (HC).
使用基于voxel的形态测量来测量GMV.
使用基于VICCCS-2标准的因果结构共变性网络 (CaSCN) 分析分析了GMV变化和因果关系.

主要成果:

与HCs相比,CSVD患者表现出特定阶段的GMV变化.
转基因病毒的减少始于右海马体,并进展到皮层-皮下区域,认知障碍恶化.
右海马体在网络中发挥着驱动作用,对其他大脑区域产生积极和消极的因果影响.

结论:

右海马是CSVD的早期病理部位.
CSVD的进展涉及到源自右海马的层次结构损伤模式.
这项研究阐明了CSVD相关脑损伤的因果影响和补偿机制.

关键词:

因果结构共变网络因果结构共变网络大脑小血管疾病大脑小血管疾病灰色物质是一种灰色物质.河马螺旋 (Hippocampus gyrus) 是一个有机体.磁共振成像技术磁共振成像技术

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